July 25, 2014   52,429 notes
platredeparis:

bnycolew:

mannysiege:

Progress

What

Imma just let this sit here

platredeparis:

bnycolew:

mannysiege:

Progress

What

Imma just let this sit here

(via prototype-the-walter-girl)

July 25, 2014   4,422 notes
currentsinbiology:

Mayo Clinic trial: Massive dose of measles vaccine wipes out cancer
Stacy Erholtz was out of conventional treatment options for blood cancer last June when she underwent an experimental trial at the Mayo Clinic that injected her with enough measles vaccine to inoculate 10 million people.
The cancer, which had spread widely through her body, went into complete remission and was undetectable in Erholtz’s body after just one dose of the measles vaccine, which has an uncanny affinity for certain kinds of tumors.
Erholtz was one of just two subjects in the experiment and the only one to achieve complete remission. But the experiment provides the “proof of concept” that a single, massive dose of intravenous viral therapy can kill cancer by overwhelming its natural defenses, according to Dr. Stephen Russell, a professor of molecular medicine who spearheaded the research at Mayo.

“It’s a landmark,” Russell said in an interview last week. “We’ve known for a long time that we can give a virus intravenously and destroy metastatic cancer in mice. Nobody’s shown that you can do that in people before.”

The research, published online Wednesday in the journal Mayo Clinic Proceedings, represents a “benchmark to strive for and improve upon,” according to an accompanying editorial by Dr. John C. Bell of the Centre for Innovative Cancer Research in Ottawa.
The next step is a bigger trial to see if the measles blitzkrieg works in a larger number of patients — a trial that Mayo expects to launch no later than September.

currentsinbiology:

Mayo Clinic trial: Massive dose of measles vaccine wipes out cancer

Stacy Erholtz was out of conventional treatment options for blood cancer last June when she underwent an experimental trial at the Mayo Clinic that injected her with enough measles vaccine to inoculate 10 million people.

The cancer, which had spread widely through her body, went into complete remission and was undetectable in Erholtz’s body after just one dose of the measles vaccine, which has an uncanny affinity for certain kinds of tumors.

Erholtz was one of just two subjects in the experiment and the only one to achieve complete remission. But the experiment provides the “proof of concept” that a single, massive dose of intravenous viral therapy can kill cancer by overwhelming its natural defenses, according to Dr. Stephen Russell, a professor of molecular medicine who spearheaded the research at Mayo.

“It’s a landmark,” Russell said in an interview last week. “We’ve known for a long time that we can give a virus intravenously and destroy metastatic cancer in mice. Nobody’s shown that you can do that in people before.”

The research, published online Wednesday in the journal Mayo Clinic Proceedings, represents a “benchmark to strive for and improve upon,” according to an accompanying editorial by Dr. John C. Bell of the Centre for Innovative Cancer Research in Ottawa.

The next step is a bigger trial to see if the measles blitzkrieg works in a larger number of patients — a trial that Mayo expects to launch no later than September.

(via odd-superbia)

July 25, 2014   1 note

Challenge #00575 - A200: Alas My Love…

An Ice Cream van on Amalgam station.

Someone, somewhere, was playing Greensleeves on a glockenspiel. Rael knew this because he was chasing Shayde, who was racing about, trying to find the source of the noise.

The only information she’d supplied had been “MISTAH WHIPPEH![1]” before she had taken off at -as she called it- warp nine.

One day, one day… in the far, far distant future, he would not need half an hour and a pocket history guide to understand anything that came out of her mouth.

But for now, all he could do was attempt to catch her before the sight of a running human caused a panic in the entire Elemeno.

"HA!" Shayde moved like an otter diving for prey as she spotted the goal of her intentions.

Which was, apparently, a luckless citizen with a freezer apparatus attached to the small food dispensary on the back of his adjusted bicycle.

He took one look at the demonic creature running towards him at top speed and took the sensible portion of valour. He attempted to escape.

They got three times around Promenade Park before Shayde pulled out a Two Hour note and called, “Wait oop! I wanted tae buy sommat!”

Citizens quickly learned that having an ice-cream cart was one thing, but a repetitive and recognisable tune earned literally terrifying volumes of customers.

And Shayde was a terrifying volume all by herself.

[1] Mr Whippy is a popular chain of ice cream vans in Australia. Once upon a time, they all played a tinkly, music-box version of Greensleeves. And routinely amazed parents with their progeny’s capability for over-the-horizon detection of said vans.

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July 24, 2014   1 note

Return to Sesame Street!

A while back you posted a horror-splash about a the terror that a hyper-realistic Sesame Street would be. I’d like to see this world reconciled back into the treasured childhood series, rather than as a grim-dark reboot. After the adrenaline-fueled shock wears off, have your protagonist step back, take a deep breath, and realize they’re not really scary at all. I realize this may be a bit specific, but for my peace-of-mind, and that of everyone who grew up on the Street, could you please consider it?

[AN: True horror is the normal gone wrong. Disturbing is, evidently, one’s childhood icons taken to realistic and horrific depths. Original post is here]

(#00574 - A199:)

Big Bird deliberately didn’t move from his nest. The stranger was very scared. He lowered his voice to a murmur and hunkered as small as he could get in his nest.

"It’s okay," he soothed. "You’re new here. You aren’t used to how things are."

Squeaking noises and sad attempts to dig through fence palings and bricks with his shoulder blades.

"It’s okay to be scared," cooed Big Bird. "I get scared of lots of things. That’s why I asked Mister Looper to keep the light above his shop on for me."

"…hooper…" squeaked the stranger.

"Beg pardon?"

"It’s Hooper. Not Looper."

"That’s right," big Bird cheered - but made sure to cheer quietly. "I keep messing it up, but it’s okay. One day, I’m going to get it right." He offered his teddy. "I know you’re scared of me, but Teddy is great for hugs. He’s all soft and there’s no sharp bits."

"Nah’m good." Pant pant pant. "Thanks."

Big Bird put Teddy down on a nearby chair, anyway. Just in case. “The scaredest I ever was? That would have to be the time all the lights went out, all over the city. It was so dark and Miss Nell came and held my hand and showed me the stars and the moon… I could see the whole galaxy, up in the sky.” Big Bird forgot himself and gestured expansively above his head. The man whimpered and Big Bird tucked his wings in again. “I was almost sad when the lights came on again,” he added. “Miss Nell was right… there’s always a light. If you know how to look.”

He’d slumped down into a sitting position in his corner. “What about the other monsters?”

"Other…? Oh, like Mr Snuffleupagus and Grover and Oscar and all the rest?"

Nod.

"They only look scary. I promise they’re all nice. Even Oscar’s nice, in his own way."

"…they’re so much… sharper… here." A helpless look upwards. He looked so lonely. "Even you’re… sharper…"

"Sometimes," said Big Bird, "people need sharp. I bet you have some sharp bits, too. The important part is to only use them when you need to, and not hurt people with them."

The stranger winced. “Yeah. I’ve hurt people and regretted it.” He got up and took up Teddy from the chair to hug it while he sat there. “Maybe I could stay here a while and learn a few things.”

Big Bird leaned down to whisper, “That’s why all the humans come.”

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July 24, 2014   2 notes

shkspr1048 said: I saw this Cracked article on Tumblr, and thought it was right up your alley. I can't post links in these ask boxes, but try Googling for this: "5 Uncomfortable Truths Behind the Men's Rights Movement".

I’m regretting counting this as a prompt, now.

Linkie here.

And I can’t really turn this into a story without setting up an obvious strawman to take pot-shots at. And in the wake of the Reddit Raid, I’d rather not make some touchy types aim a DDOS nuke at my poor ageing compy.

…besides, I agree with practically everything in that article…

So I’ll take on another argument I saw in another post.

“‘Not all men’ should be be ‘might as well be all men’,” sounds bad when you substitute other groups for ‘men’. There’s a comic I’ve seen around on the subject claiming that feminists can’t counteract that one.

I’m going to have a go.

Statistics and numbers make that particular argument a fallacy. One in ten men will admit to being rapists if you avoid using the word ‘rape’. That’s ten percent of men. You would not enter a lottery in which there was a one in ten chance you would ‘win’ a brutal and violent death, would you? You wouldn’t dip into a bowl of skittles or M&Ms if one tenth of them contained arsenic instead of delicious sugary goodness. [And time and time again, women are blamed and called “stupid bitch” for daring to trust her rapist by the same men who say ‘not all men’. But that’s another argument.]

Now let’s look at the ‘racist’ argument… “Not all POC’s(etc)”. That’s a bad argument because statistics are on the POC’s side. The rates of crime in POC populations are MASSIVELY lower than the rates of crime in white populations. And as for violent crime, again, the whites come out as worse aggressors. Yet our racist society insists on convicting the POC in much larger proportions than the white criminals. It perpetuates the myth that POC are more violent and and prone to violence when the opposite is factually true. Therefore, “Not all POC are criminals” is a true statement and doesn’t need to be expanded to the entire group.

The same holds true with “Not all Muslims are terrorists”. The terrorist-to-Muslim ratio is something like one in one astronomically large number. Yet we believe innately that terrorists are exclusively non-white and non-christian. Why? Because terrorist action from Muslim extremists is played up and touted loud and proud… while the more numerous violence from straight white christians is downplayed as mental illness. [And the hue and cry about better mental health care is strangely conspicuous by its absence…]

And while we’re on the topic… the number of proven mental illnesses in relation to violent crime remains at an unproven minimum of This One Guy One Time.

The statistical evidence supports women trusting mentally ill Muslim POCs better than they can trust a straight, sane, white Christian man.

And I fully expect an inbox full of straight white male anger because of this point. Yet they call women ‘too emotional’.

July 24, 2014   49,494 notes

beringandwellscrew:

rmlfvr:

These classical musicians play their instruments in a way you’ve never seen before.

A rather compelling visual experience, on top of being a flawless musical demonstration, performed by Salut Salon, a charming German quartet from Hamburg. 

WOW!!!!
Just WOW!!!

(Source: youtube.com, via buntern)

July 23, 2014   1 note

dakhur : I have done your first prompt. Celebrate.

I bet it’s not what you expected :D

July 23, 2014

Challenge #00573 - A198: One Fine Evening in the Nightvale Maternity Ward

“Slowly, the doctor turned. Extending a pointing finger, he said “But … but that’s an orange … !””

"Yes," said Mrs Murray. You know her, she was born with octupoid-like tentacles instead of hair.

"We couldn’t be happier," said Mr Murray, through the independently levitating ouija board that is his sole means of communication. Since he is corporeally-challenged.

"All we want to know," asked Mrs Murray carefully, "is to the signs and portents indicate a girl orange, a boy orange, or something in-between."

"We want to use the correct pronouns from the get-go," said Mr Murray.

At which point, Doctor Smith turned and fled from the nursery, and was last seen headed towards the cactus grove where the waterfront boardwalk never actually existed.

We of course wish Doctor Smith a quick and speedy recovery from his retrograde amnesia. We are also assured that the Sherrif’s Secret Police are going to keep an eye on him as he walks uncertainly between the venomous cactii and attack-trained triffids.

And now… the weather.

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July 23, 2014   322,694 notes

goldstarprivilege:

muchymozzarella:

afunnyfeminist:

ghastderp:

i love sir patrick stewart more with each passing day.

See, guys. This is how you do it. Notice the words “Not all men are like that” are never spoken.

He knows men are like that

his father was like that to his mother

he has experienced the pain firsthand, of what it’s like when men are like that

and he never wants men to be like that again and he fights tooth and nail against the men who are still like that

And moreover, he acknowledges his privilege [as an older white male who is famous/well known] and uses it to speak up. He knows what he is, and he never has to say he’s not like those men he fights against—he never says it, his actions speak loud enough for everyone else to see it. 

Sir Patrick Stewart, everyone.

(Source: vastderp-placeholder, via meefling)

July 22, 2014   32,762 notes

Hi guys. we need to have a serious chat right now.

jackthevulture:

snoopycomet:

saracastically:

blueskyesartic:

the-fury-of-a-time-lord:

Two years ago, there was a movie called Paranorman.

image

It didn’t do so good at the box office, despite it being one of the most important, game changing animated movies since the Disney renaissance. It made its money back, but it wasn’t the smash hit Frozen was.

And this is a fucking tragedy. 

Why?

image

image

People read into Frozen that Elsa was an allegory for many things, one of them being LGBT. That’s cute. Meanwhile, Paranorman had the first ever openly, proudly gay character in an animated movie. ever. There was no allegory, there was no “well if you squint”. HE WAS GAY. HE HAD A BOYFRIEND. And Tumblr didn’t make this movie a smash success. There wasn’t a million mash ups with this and Return of the Guardians and HTTYD and Brave or whatever. There wasn’t long posts reading into Agatha Penderghast and how they handled bullying. This movie had a smallish following and fell off the map.

Now, Laika has a new movie coming out.

People are scared for Dreamworks right now. The news that if HTTYD 2 doesn’t do well, they’re going to lay off a bunch of animators is terrible. Don’t get me wrong. But Laika is a small company doing fantastic things. Everyone loved Coraline. Great, where was your money when it counted? Coraline didn’t do fantastic either. This is a SMALL STUDIO. THEY NEED ALL THE HELP YOU CAN GIVE THEM. All the money you threw at Frozen, a far inferior film, could’ve gone to a movie that mattered. 

(just putting it out there, I liked Frozen. But Paranorman was not even in the same ballpark of quality).

image

what i’m trying to say is, Laika needs to be protected at all costs. It isn’t wrong to love the big three of Disney/Dreamworks/Pixar, but small companies deserve a chance to grow just as big. there is room in the industry for new and beautiful things, and Laika is SO going to be the frontrunner for this. Their movies are, so far, dark and challenging, beautiful and haunting, and innovative. Give them a reason and a means to make more movies. 

Go see the Boxtrolls. Good, bad, mediocre, Laika deserves it.

Not gonna knock on any of you Frozen lovers if you liked it, but also just see Boxtrolls to appreciate the fading art of stop-motion animation.  Laika does it well and it’s an art that you can see has a lot of love put into it. 

Please support animators and these studios, they could really use the help right now.

look, guys, it is extremely important that studios like laika, dreamworks, and blue sky exist and do well. if disney gets a monopoly on animation, we’ve just told them that we are a-okay with films that use characters with no diversity, even in their facial structure; films with stories that have big plot holes and convoluted progressions; films that capitalise on sales before the infinite possibilities of animation. disney is limited, and they do it to themselves.

so go see boxtrolls. take a chance on something a little different, or it will all start looking the same.

It’s pretty sad when you see people complaining about how Disney needs more diversity with race and body image, and how all their recent female characters all look the same. Meanwhile, there are animation studios out there doing that are doing just that, but no one is giving them the chance because they’re still waiting for Disney to do the same.

If you want to start seeing more risks in animated movies, then go see then animated movies that are actually taking these risks. The ones that do have characters of various ethnicities, and body shape. The ones that do have LGBT characters. Just because Disney hasn’t done it doesn’t mean it hasn’t been done.

Can not agree enough.  I think one of the worst examples is how everyone was complaining about Frozen, but I still see very little love for the Croods, which came out the same year, and had an INCREDIBLY unconventional female lead design. And she was fantastic.  And also, god bless Laika. They make stop motion animation on faces look fluid.  Thats a hell of a feat considering ever different movement on the face has to be a separate face entirely. Laika are wizards and they deserve more love.  And their stories are creative as well. I really think they get KIDS in a way a lot of people dont.  They write kids like actual kids, and they write them into stories that kids that age might like.  And its awesome. 

Signal boost.

(via meefling)